Firefighters are battling a fire at an unused Motel in Bullarto, near Daylesford.
CFA was called to the fire on Daylesford-Trentham Road around 10.40am, on arrival they found the Motel fully engulfed.
One gas cylinder on site released during the fire.
There are no reported injuries as a result of the fire.
Victoria Police will investigate alongside CFA as the cause has been deemed suspicious.
Nine CFA trucks are on scene.